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Open access Sep 2026

Diffusion MR Microscopy of the Human Hippocampus at 50 μm Resolution at 14.1 T for 3D Virtual Histology

Bridging the gap between macroscopic neuroimaging and microscopic histology remains a challenge in neuroscience. Here, we present a technical feasibility study of diffusion MR microscopy (dMRM) in the ex vivo human hippocampus using a 14.1 T ultrahigh-field MRI system. Mid-hippocampal blocks from control and Alzheimer’...

Yao Shen, Zi-Yang Yu, Qin-Feng Zhu et al. · 0 citations
Open access Aug 2026

HSPA8 orchestrates SNARE complex assembly to drive extracellular vesicle-mediated spread of p-tau217 in Alzheimer's disease

Dysregulation of multivesicular bodies (MVBs) in Alzheimer’s disease (AD) contributes to aberrant tau secretion via extracellular vesicles (EVs). This may potentially explain our previous paradoxical observation of elevated free-form p-tau217 alongside reduced p-tau217+ EVs in plasma. This study aimed to investigate th...

Bin Xu, Zhen Guo, Jun Chen et al. · 0 citations

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