BACKGROUND
Sleep disorders are common in adolescents with major depressive disorder (MDD), with an incidence rate surpassing that of low mood. Nonetheless, the effects of sleep disturbances on brain function in adolescent MDD remain unclear.
METHOD
97 right-handed, untreated adolescents with MDD and 63 healthy controls (HCs) underwent proton magnetic resonance spectroscopy (1H-MRS) scans of the anterior cingulate cortex (ACC) and putamen. Differential and association analysis examined the relationship between sleep quality, depression severity, and neurometabolic ratios of ACC and putamen in MDD groups.
RESULTS
Among 97 MDD patients, 64 were categorized into the insomnia symptom (IS) group, with an insomnia item score ≥ 1 on Hamilton Depression Rating Scale (HDRS) and a Pittsburgh Sleep Quality Index score ≥ 6. IS group exhibited significantly lower choline-to-creatine (Cho/Cr) ratios in the right ACC compared with the NIS group and HCs, and a higher Cho/Cr ratio in the right putamen compared with HCs. NIS group showed lower N-acetylaspartate-to-creatine (NAA/Cr) ratios in the right putamen compared with the IS group and HCs. Within the IS group, HDRS scores showed nominal negative correlations with NAA/Cr ratios in the bilateral ACC and Cho/Cr ratios in the right ACC. Insomnia item scores were nominally correlated with Cho/Cr ratios in the left ACC. However, these correlations did not survive FDR correction.
CONCLUSION
A substantial proportion of adolescents with depression experience sleep disturbances, which may be associated with altered brain neurometabolism. These preliminary findings highlight the need for further investigation into the neurobiological relevance of sleep disturbances in adolescent MDD.
Yutong Liu, Qilin Zhong, Liu Peng et al.· Journal of Affective Disorde...· 0 citations
INTRODUCTION
White matter (WM) tract function has only recently been investigated. However, whether WM function is altered in individuals with subthreshold depression (StD) remains largely unknown.
OBJECTIVES
To examine WM functional alterations in StD and their associations with cognitive performance, neurotransmitter systems, and gene expression patterns.
METHODS
A total of 188 individuals with StD and 136 healthy controls (HCs) were recruited from XXX University in the study. Participants underwent mood and cognitive assessments, as well as resting-state functional MRI.WM function was evaluated using the amplitude of low-frequency fluctuations (ALFF) in conjunction with the automated fiber quantification (AFQ) method. Correlation and linear regression analyses were performed. Subsequently, spatial associations between postmortem gene expression/neurotransmitters and WM functional alterations were investigated to uncover neural mechanisms underlaying StD from a multidimensional perspective.
RESULTS
Individuals with StD showed decreased social cognition and composite cognition compared to HCs. Individuals with StD displayed ALFF decrease in the right anterior thalamic radiation (ATR), inferior fronto-occipital fasciculus, inferior longitudinal fasciculus (ILF), and uncinate fasciculus. Rumination and depressive symptoms were associated with ALFF decrease in the right ATR; anxiety symptom was associated with ALFF decrease in the right ILF. Moreover, the abnormal pattern of WM function in StD was spatially associated with modulation of chemical synaptic transmission, regulation of synaptic plasticity, cation channel activity, and neuron projection, as well as dopaminergic and serotonergic neurotransmission.
CONCLUSION
To conclude, these findings reveal WM functional alterations in StD that are associated with mood and cognitive disturbances, and suggest that these alterations may be linked to underlying transcriptomic and neurotransmitter correlates. This study provides new clues to understand the neuro-pathophysiology of StD.
Zixuan Guo, Pan Chen, Guanmao Chen et al.· Journal of Advanced Research· 0 citations
Findings reveal concurrent thyroid hormone irregularities and neurometabolic changes in the thalamic-cerebellum circuitry in MDD with ED, providing preliminary insights into the neurobiology of abnormal eating behaviors in depression.
Yangyu Wu, Qilin Zhong, Jianzhao Zhang et al.· Eating and Weight Disorders· 0 citations
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