Author

Pablo Fuentes-Prior

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Review Open access Jul 2026

On the structure and function of granzymes, the deadly squad of cytotoxic lymphocytes

It is highlighted how specific variations of the canonical trypsin fold allow these five proteinases to display entirely distinct substrate specificities, and the role of allosteric mechanisms, such as exosites and dimerization, in expanding their substrate recognition profiles far beyond simple P1 cleavage site requir...

José Luis Gardeazábal-Torbado, E. Estébanez-Perpiñá, Pablo Fuentes-Prior · Biological chemistry · 0 citations

#protein folding Review Open access Aug 2026

Structural basis for the procoagulant activity of Staphylococcus aureus staphylocoagulase

3D models of the C-terminal SC region suggest that the major C-terminal domain of SC folds into a single-layer β-sheet structurally similar to the membrane occupation and recognition nexus (MORN) family of tandem repeats, which is critical for understanding SC-mediated fibrin generation.

Pablo Fuentes-Prior, A. Maddur, Peter Panizzi et al. · Biological chemistry · 0 citations