Reader-dependent functional duality of FTO: a context-switching node at the intersection of immune evasion and therapeutic resistance
The fat mass and obesity-associated protein (FTO), an RNA demethylase acting on both internal m6;A and cap-proximal m6;Am, functions in cancer as a context-dependent epitranscriptomic regulator whose net effect cannot be reduced to an oncogene–tumor-suppressor dichotomy. Its biological output is shaped by tumor lineage...