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P. Wolynes

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Open access Sep 2026

CaMKII generates actin bundle morphology and mechanics distinct from canonical bivalent cross-linkers

Actin cross-linkers are essential modulators of the actin cytoskeleton, enabling structural diversity and dynamic remodeling. Among them, calcium/calmodulin-dependent protein kinase II (CaMKII) is unique in serving a dual role as a kinase and as a multivalent structural binder of actin in dendritic spines, where it pla...

Sofía Vargas-Hernández, Carlos Bueno, Madiha Syeda et al. · 0 citations
Review Open access Sep 2026

From static structures to dynamic energy landscapes: the latest revolution in molecular biology.

Over a decade ago, in an Editorial, we proposed that beyond the foundational discovery of the DNA double helix, modern molecular biology has undergone a second revolution: a shift from static, single-structure models to dynamic, ensemble-based energy landscapes that define biomolecular function. Recently, Quarterly Rev...

R. Nussinov, H. Jang, P. Wolynes · 0 citations

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