Author

P. Verstreken

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Review Open access Oct 2026

Tau phosphorylation from neuronal adaptation to Alzheimer's disease.

Tau phosphorylation is classically associated with neurodegeneration, yet similar phosphorylation patterns emerge during physiological states and acute stress responses. How these overlapping patterns of phosphorylated Tau (pTau) relate to neuronal adaptation and Alzheimer's disease pathology remains unresolved. We syn...

Ryan Trouvé, P. Verstreken, M. Hoekstra · Neuron · 0 citations

Open access Sep 2026

Excessive activation of the RAS/MAPK pathway triggers adult-onset motor axonal degeneration

Summary Axonal and synaptic degeneration are key hallmarks of neurodegenerative diseases, but the molecular mechanisms remain incompletely understood. Here, we performed an unbiased forward genetic mosaic screen in Drosophila to identify genes required for maintenance of adult motor axons and neuromuscular junctions (N...

Marije Been, Erwan Lambert, Ana Serna et al. · iScience · 0 citations