P. Vanden Berghe

Endothelialized callus organoids drive rapid regeneration of critical-size segmental long bone defects.

Large bone defects remain a major clinical challenge, as current treatments cannot effectively regenerate them and fail to restore functionality. To recapitulate the cellular complexity of the early fracture callus, we engineered human endothelialized callus organoids (hECOs) by co-culturing periosteum-derived skeletal...