Author

P. V. van der Meer

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Open access Oct 2026

Impact of age on implementation and tolerability of guideline-directed medical therapy in heart failure with reduced ejection fraction

Elderly patients constitute a growing proportion of patients with heart failure with reduced ejection fraction (HFrEF), yet remain underrepresented in randomized clinical trials shaping treatment recommendations. We evaluated age-related differences in real-world contemporary HFrEF care. TITRATE-HF is a pr...

J. J. N. Krabbe, M. I. Wilde, W. L. Verloop et al. · European Heart Journal · 0 citations

Review Open access Aug 2026

Shifting the Balance: Mitochondrial Heteroplasmy as a Driver of Cardiac Disease

Mitochondrial heteroplasmy represents a fundamental determinant of mitochondrial function and disease, yet its consequences vary across different tissues. Although mitotic tissues possess mechanisms, such as cell division and mitochondrial turnover, to dilute or remove deleterious variants, postmitotic tissues lack thi...

Andriana Papadaki, Itamar Braga Dias, C. Maack et al. · Circulation Research · 0 citations

Open access Jul 2026

Differences between men and women in guideline-directed medical therapy implementation, tolerability, and outcomes in heart failure with reduced ejection fraction.

The findings underscore the need for implementation and dosing strategies that account for differences between men and women regarding GDMT implementation, side effects, change in left ventricular ejection fraction (LVEF), and clinical outcomes.

M. I. Wilde, J. J. N. Krabbe, L. J. Bouhuijzen et al. · European Heart Journal - Qua... · 0 citations