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P. Vacca

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Open access Jul 2026

Multifunctional-engineered NK cells overcome tumor immunosuppression by combining PD-L1 and HLA-E targeting and endogenous IL15 production

A next-generation NK cell platform using a tri-cistronic retroviral vector that encodes an extracellular PD-1 domain fused to the intracellular portion of NKG2D with the costimulatory molecule 4-1BB and induces de novo PD-L1 expression in otherwise negative tumors is developed.

P. Fiore, Sergio Forcelloni, Lorenzo Moretta et al. · 0 citations

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