P. V. van Lith

Excessive activation of the RAS/MAPK pathway triggers adult-onset motor axonal degeneration

Summary Axonal and synaptic degeneration are key hallmarks of neurodegenerative diseases, but the molecular mechanisms remain incompletely understood. Here, we performed an unbiased forward genetic mosaic screen in Drosophila to identify genes required for maintenance of adult motor axons and neuromuscular junctions (N...