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P. Slomka

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Open access Oct 2026

Ascending Aortic Calcium Identifies Patients at Risk Despite Normal Myocardial Flow, Perfusion and Coronary Calcium: A 13-Site Cohort Study

Background Patients with normal perfusion, normal myocardial flow reserve (MFR) and no coronary artery calcium (CAC) on myocardial perfusion imaging are considered low risk. Yet, adverse events still occur and no routinely reported imaging marker stratifies residual risk. This study aims to determine whether fully auto...

C. Spielvogel, A. Shanbhag, S. Khanna et al. · 0 citations
Open access Oct 2026

Improved plaque composition from intensive medical treatment in women with angina and non-obstructive coronary disease.

AIMS Among women with suspected ischaemia and non-obstructive coronary artery disease (INOCA), the temporal effect of combination intensive medical treatment (IMT) with angiotensin-converting enzyme inhibitors or receptor blockers, statins, and aspirin on coronary plaque composition is not known. This prospective ancil...

J. Lenell, Guadalupe Flores Tomasino, Donghee Han et al. · 0 citations
Open access Sep 2026

Artificial intelligence-derived splenic response in cardiac positron emission tomography is associated with major adverse cardiovascular events: a multi-site study.

AIMS Inadequate pharmacologic stress may limit the diagnostic and prognostic accuracy of myocardial perfusion imaging (MPI). The splenic ratio (SR), a measure of stress adequacy, has emerged as a potential imaging biomarker. We developed an artificial intelligence (AI) method to derive SR and evaluated the prognostic v...

G. Ramirez, Naga L. Dharmavaram, A. Shanbhag et al. · 0 citations
Review Sep 2026

Beyond stenosis: imaging phenotyping and risk stratification in nonobstructive coronary artery disease.

CCTA is evolving into a multidimensional phenotyping tool for NOCA; its immediate value is refined risk stratification; whether these markers will improve outcomes remains unproven and should be tested prospectively.

P. Piña, A. Filtz, Daniel Lorenzatti et al. · 0 citations
Review Open access Jan 2026

Cardiac CT for personalized phenotyping in stable coronary artery disease: toward precision medicine

An overview of CCTA derived plaque features in CAD and associated imaging biomarkers of risk are provided to highlight their potential applications in precision phenotyping and individualized management decisions and outlines anticipated future developments that may enable widespread clinical adoption of these novel im...

J. Lenell, K. Grodecki, J. Kwieciński et al. · 0 citations
Open access Aug 2026

Clinical Reference Percentiles for AI-derived Epicardial Adipose Tissue: A Multicenter Study

Age- and sex-specific EAT percentiles provide a clinically interpretable framework for contextualizing automated EAT measurements and identifying patients at increased cardiovascular risk and identified elevated risk even among patients with normal BMI.

A. Kamagate, A. Shanbhag, M. Buchwald et al. · 0 citations
Open access Sep 2026

Quantitative coronary artery and aortic valve calcification by virtual non-contrast Images from dual-energy delayed CT scans in patients with severe aortic stenosis.

Delayed VNC images from DECT demonstrate strong agreement with TNC images for CACS and AVCS, suggesting that delayed VNC could potentially reduce the need for TNC acquisition in pre-TAVR assessment.

H. Fujito, K. R. Bookani, B. Gheyath et al. · 0 citations

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