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Compared to males, female patients with DLB were less likely to present with Rapid Eye Movement (REM) Sleep Behaviour Disorder, CSF biomarkers showed more Alzheimer’s Disease (AD) co-pathology, potentially contributing to misdiagnosis of DLB.
This patient-specific iPSC line provides a valuable resource for generating choroid plexus organoids and neurons to investigate disease mechanisms and develop therapeutic strategies to investigate disease mechanisms and develop therapeutic strategies.
In vivo evidence is provided for choroid plexus dysfunction in a maternally inherited disorder with convergent evidence supporting a mitochondrial aetiology, associated with reduced CSF production and impaired blood–CSF barrier transport, substantially altering biomarker profiles in the absence of cortical atrophy or b...
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