Optimization and Evaluation of Microsponge-Embedded Thermoresponsive In-Situ Gel for Intranasal Delivery of Sumatriptan Succinate
Migraine is a prevalent neurological disorder requiring rapid and effective therapeutic intervention. However, the conventional oral administration of Sumatriptan succinate (SS) is limited by extensive first-pass metabolism, low bioavailability, and a short biological half-life. This study aimed to develop and optimize...