Author

P. Saw

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Open access Oct 2026

Mitochondria-localized circRNA BRAKE restrains adipogenesis under nutrient overload by disrupting ATP synthase assembly in mice

Impaired adipogenesis contributes to obesity-associated metabolic disorders, in which mitochondrial dysfunction plays an important role. Emerging evidence suggests that mitochondria-localized circular RNAs (circRNAs) influence mitochondrial function; however, whether they regulate adipogenesis and systemic metaboli...

Yan-Rui Huang, Tian-Xing Zhu, Xiao-Si Hong et al. · Nature Communications · 0 citations

Open access Aug 2026

Engineered bacteria reverses tumor cuproptosis resistance via cancer-associated fibroblast reprogramming for enhanced immunotherapy

Cuproptosis, a novel modality of mitochondrial copper-induced cell death, holds great therapeutic potential against cancer. However, its efficacy is limited by cancer-associated fibroblasts (CAFs), which confer the cuproptosis resistance in tumor by upregulating the copper exporter ATP7A. In this study, we developed an...

Yu-Hao Chen, Xiao-Rui Geng, Ning Su et al. · Materials Today Bio · 0 citations

Review Open access Sep 2026

ATF3: Friend or foe in cellular stress and repair? A context-dependent stress rheostat framework.

Activating transcription factor 3 (ATF3) is an immediate-early basic leucine zipper transcription factor induced by diverse forms of cellular stress. Although ATF3 is often described as a "double-edged sword," that formulation alone does not explain why the same stress-responsive factor can accompany successful adaptat...

Rong Huang, Rui-Kang Li, P. Saw et al. · European Journal of Cell Bio... · 0 citations