These findings provide a comparative molecular-pathology framework for interpreting NOTCH3 variation beyond cysteine number alone and support a context-dependent model in which residue position, disulfide architecture, surrounding sequence, domain organization, aggregation propensity, and proteolytic regulation jointly...
K. S. Siddiqui, H. Ertan, Yi Ren et al.· bioRxiv· 0 citations
BackgroundThe status of melancholia remains controversial. Debate has focused on whether it represents a categorically distinct disorder (binary model) or a severe expression within a unitary construct of major depressive disorder. Its defining core has also been disputed, with competing emphasis on affective symptoms,...
PURPOSE OF REVIEW
Arterial spin labeling (ASL) MRI noninvasively quantifies cerebral blood flow (CBF), but its role as a mechanistic biomarker and surrogate endpoint in trials of cognitive impairment remains undefined. This review evaluates evidence linking regional CBF to cognition across Alzheimer's disease, mild cog...
Satoshi Hosoki, P. Sachdev, M. Ihara· Current Opinion in Psychiatr...· 0 citations
Enlarged perivascular spaces (ePVS) are small, sparse MRI-visible markers of cerebral small vessel disease and brain ageing. Their size, low contrast, and severe foreground-background imbalance make automated segmentation challenging. Existing methods are mainly cross-sectional and do not model temporal consistency, li...
S. Hayashi, Lei Fan, Jiyang Jiang et al.· Journal of imaging informati...· 0 citations
White-matter microstructural burden and smaller L_NAcc volume may help characterize LLD patients at higher near-term risk of cognitive decline, and warrant evaluation in larger longitudinal LLD cohorts.
Chaoyue Guo, Yuan Fang, Qi Qiu et al.· International Psychogeriatri...· 0 citations
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