Distinct Treg subsets in human peripheral blood are defined by unique transcriptomic signatures 2252633
Regulatory CD4+ T cells (Tregs) are critical for maintaining tolerance to self. Chronic inflammation can cause Treg instability which is defined by loss of CD25 and the lineage-defining transcription factor FOXP3, resulting in exTreg cells. To better understand the factors driving Treg to exTreg conversion...