NEU3 at the Plasma Membrane: Context-Dependent Ganglioside Remodeling in Health and Disease.
Cell-surface gangliosides tune receptor signaling, cell-state transitions, and responses to stress. NEU3 is a mammalian sialidase associated with the plasma membrane and endomembranes that preferentially removes terminal sialic acids from gangliosides. Here, we critically review biochemical studies, cultured-cell exper...