Author

P. Pfluger

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Open access Oct 2026

Temporal organization of leptin signaling reveals distinct regulatory roles for STAT3 and ETV6.

Leptin regulates energy homeostasis through activation of its long-form receptor (LepRb), primarily via JAK2-dependent phosphorylation of STAT3. However, the temporal organization of leptin-induced transcriptional responses and how parallel signaling pathways contribute to these dynamics remain incompletely understood....

Ekta Pathak, Miriam Bernecker, Noémi Mallet et al. · Journal of Molecular Endocri... · 0 citations

Open access Oct 2026

Cyclophilin D deficiency exacerbates diet-induced obesity and selectively enhances skeletal muscle mitochondrial respiration in male mice

Mitochondrial dysfunction is a hallmark of obesity-associated metabolic disease, with the mitochondrial permeability transition pore serving as a key regulator of cellular energy homeostasis. Cyclophilin D, encoded by Ppif, is the principal regulatory component of this pore and has been implicated in insulin secretion,...

Jazzminn Hembree, William Abplanalp, John W. Elrod et al. · Pflügers Archiv: European Jo... · 0 citations

Aug 2026

Central Thyroid Hormone Deprivation Disrupts Cortical Cilia and Oligodendrocyte Lineage in an Allan–Herndon–Dudley Syndrome Mouse Model

These findings provide the first single-cell–level cortical map of AHDS brain pathology, revealing cilia defects, excitation–inhibition imbalance, differing pseudotime trajectories in glutamatergic neuronal populations and altered oligodendrocyte maturation, with actionable candidate genes such as Lama2, Litaf, and Dcc...

Anna Molenaar, Ekta Pathak, Miriam Bernecker et al. · Thyroid · 0 citations