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Author

P. Oeckl

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Open access Sep 2026

Changes in serum β‐synuclein precede blood biomarkers of Alzheimer pathology in Down syndrome

There is a need for early, objective markers of Alzheimer's disease (AD)‐related synapse dysfunction in adults with Down syndrome (DS). The presynaptic protein β‐synuclein is elevated in the blood of adults with DS. This study evaluates the positioning of these changes relative to changes in pathophysiological blood bi...

Alba Cervantes González, A. Morcillo-Nieto, Sara Serrano et al. · 0 citations
Open access Jul 2026

Longitudinal trajectories of neurodegenerative biomarkers in the blood of patients with chronic heart failure

Serial biomarker assessment provided stronger prognostic information than baseline measurements alone in clinically stable patients with chronic HF, and longitudinal increases in circulating amyloid-β peptides associated with cognitive decline, structural brain changes, and mortality.

J. Traub, Anna Frey, G. Homola et al. · 0 citations
Open access Jun 2026

A rare missense variant impacting NEK1 kinase function is associated with ALS

Findings provide strong genetic and functional evidence for a disease-causing role of NEK1 kinase disruption in NEK1-ALS and provide immediate diagnostic and therapeutic implications, particularly for the functional interpretation of missense variants of uncertain significance and the development of targeted treatment...

David Brenner, Anna Ponomarenko, Iris Petrut et al. · 1 citation

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