Lipid-dependent regulation of Kv10.1 in cancer: implications of membrane remodeling for channel function and pharmacology
The voltage-gated potassium channel Kv10.1 (Eag1), which is abnormally overexpressed across a wide range of tumor types, is a promising therapeutic target for cancer treatment. However, the clinical development of Kv10.1 inhibitors is currently constrained by severe off-target cardiotoxicity resulting from unintended i...