Hypoxia is a defining feature of the solid tumor microenvironment and a central driver of cancer-stem-cell (CSC) biology, yet the epigenetic mechanisms linking oxygen deprivation to stemness, metastasis, and therapy resistance remain fragmented across the literature. This review synthesizes that evidence into a unified...
M. Al-khreisat, Rustam Narzikulov, O. Allela et al.· Gene· 0 citations
Metabolic dysfunction-associated steatotic liver disease, hepatotoxicity, liver fibrosis, and hepatocellular carcinoma are stages of chronic liver injury that occur in the setting of complex interactions of the various factors, including metabolic dysregulation, inflammation, oxidative stress, and cellular senescence....
Amr A. El-Sehrawy, Safa H. Radhie, Mirza R. Baig et al.· Journal of Pharmacology and...· 0 citations
Solute carrier family 7 member 11 (SLC7A11), the functional subunit of the cystine/glutamate antiporter, is described as a major context-dependent regulator of hepatic ferroptosis, which provides protection from ferroptosis caused by different kinds of liver damage.
J. Gupta, Musaab Hamid Farhan, A. Smerat et al.· Tissue & Cell· 0 citations
The metabolism of neuronal activity is highly localized and cannot be sustained by cell-wide distribution of energy. Neurons and glia organize metabolic enzymes, mitochondria, lipid droplets, and endoplasmic reticulum (ER) contacts into spatially localized microdomains that dynamically couple energy generation to synap...
S. Mohammad, A. K. Kareem, M. Rekha et al.· Neurochemistry International· 0 citations
The molecular mechanisms by which NRF2 regulates ferroptosis, including KEAP1-NRF2 signaling, metabolic rewiring, iron homeostasis, lipid remodeling, and crosstalk with p53 and other stress-response pathways are summarized.
S. Mohammad, A. Vasudevan, S. Rodrigues et al.· Asia-Pacific Journal of Clin...· 0 citations
The fundamental immunosuppressive interactions within the TME are discussed and subsequently it is examined how these agents enhance immune responses by reprogramming stromal and immune cells, as well as their secreted mediators within the TIME.
Qamar Abuhassan, Usamah Sayed, Pareshkumar N. Patel et al.· Advanced Pharmaceutical Bull...· 0 citations
Increasing clinical evidence indicates that elevated TWIST1 expression is associated with poor clinical outcomes, higher metastatic burden, and reduced treatment efficacy, emphasizing its importance as a prognostic biomarker and a potential therapeutic target in breast cancer management.
K. Saleh, R. S., P. Nayak et al.· Mutation research. Reviews i...· 0 citations
It is concluded that understanding the brain as a dynamic mosaic of billions of distinct genomes—rather than a single‐genome organ—is essential for accurate disease modelling, diagnostics and the development of targeted therapies.
Maher Abdulrazzaq Al-Hakeem, Y. Q. Almajidi, S. Alshkarchy et al.· European Journal of Neurosci...· 0 citations
Current evidence on TAM‐driven chemoresistance in GC is synthesized, highlighting the molecular interplay between TAMs, tumor cells, and stromal components and underscores the potential of TAM‐centric therapies to overcome resistance and improve clinical outcomes.
S. Abdul-Rahman, Abdulkareem Shareef, S. Jyothi et al.· Cell Biology International· 0 citations
This review synthesizes available evidence indicating that several KIFs, specifically KIF4A, KIF14, KIF20A, and KIFC1, function as key oncogenic regulators and represent important prognostic biomarkers and therapeutic targets in bladder cancer.
Usamah Sayed, Noor Mazin Basheer, M. H. et al.· Cell Biology International· 0 citations
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