Novel biofilm-targeted therapeutics for oral infections: enzymes, EPS disruptors, phage/CRISPR, photodynamic and cold-plasma approaches — a systematic review
Five mechanistically distinct modalities — matrix-degrading (anti-biofilm) enzymes, extracellular polymeric substance (EPS) disruptors, bacteriophage and CRISPR-based therapy, antimicrobial photodynamic therapy (aPDT), cold atmospheric plasma (CAP) and cold atmospheric plasma (CAP) — are systematically mapped and appra...