An integrated single-nucleus transcriptomic atlas of skeletal muscle is generated, identifying transcriptionally distinct condition-specific myonuclear states, including disease-responsive programs within synaptic myonuclei at the neuromuscular junction, that are shared or distinct between the two conditions.
Mercedes Grima-Terrén, Megan K. Rommelfanger, Silvia Campanario et al.· Proceedings of the National...· 0 citations
This work focuses on the age-associated intrinsic changes of SCs and the causes of their cellular and molecular decline, and discusses results from single-cell omics technologies that have shed light on the interactions between SCs and niche cells and how far-reaching signals impact SC function.
Joana Neves, Pedro Sousa-Victor, P. Muñoz-Cánoves· Cold Spring Harbor Perspecti...· 0 citations
A comprehensive transcriptomic and chromatin accessibility atlas of 8 brain regions of 23 female cynomolgus macaques spanning the adult lifespan, including exceptionally old individuals establishes a foundational framework for understanding the cellular and regulatory architecture of primate brain aging and its links t...
