Open access
Aug 2026
A TMEM63B variant with enhanced mechanosensitive channel activity and acquired lipid scramblase function
A stratified molecular model of TMEM63B channelopathies in which the pathogenic variants progressively destabilize the hydrophobic gate, permitting lipid permeation at the resting state followed by force-induced ion and lipid co-transport through I475del is supported.
Augustus J. Lowry, P. Liang, Maria A. Gonzalez Torres et al.
· The Journal of General Physi... · 0 citations