Open access
Jul 2026
Developmental mis-specification of cardiac conduction and structure transcriptome in Brugada syndrome
The findings support a model in which non-SCN5A BrS is associated with early dysregulation of developmental transcriptional networks controlling cardiac conduction and extracellular matrix organization, whereas SCN5A-mediated BrS primarily results from sodium channel deficiency with limited developmental remodeling.
T. Stervinou, B. Cimarosti, R. Canac et al.
· medRxiv · 0 citations