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Author

P. Leigh

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Open access Oct 2026

TRICALS risk score augments but cannot replace neurofilament as a prognostic biomarker in ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with substantial clinical heterogeneity, complicating the design and interpretation of clinical trials. Two strategies have been proposed to address this variability: phenotype-based prognostic modelling and biomarker-based stratification using neurofi...

Ahmad Al-Khleifat, A. Malaspina, J. Kirby et al. · 0 citations

Neurobiology of Aging

The pathology of PSP causes clinically relevant changes in neural temporal dynamics, leading to a greater proportion of time in inefficient brain-states, leading to a greater proportion of time in networks associated with higher cognitive functions.

D. Whiteside, P. S. Jones, B. Ghosh et al. · 0 citations

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