P. Kochunov

Thalamic Dysconnectivity and Negative Symptoms in Schizophrenia Spectrum Disorder

Background and Hypothesis Negative symptoms in schizophrenia spectrum disorder (SSD) are associated with poor functional outcomes and reduced quality of life; however, effective treatments remain limited. A better understanding of the underlying brain mechanisms is needed to develop better treatments. Neuroimaging stud...

From Sensorimotor to Transmodal Cortex: Sleep Quality Aligns Brain Entropy with the Cortical Functional Gradient.

A neural signature of sleep deprivation in the human brain

The reliability and generalizability of this neural signature underscore its potential as a biomarker for understanding and monitoring the neural impacts of acute and chronic sleep loss.

Clinical, cellular, and genomic consequences of a population-enriched SETD1A missense variant

Findings link a population-enriched missense variant to disrupted chromatin regulation, genome stability, and neurodevelopmental timing, bridging human genetic risk with cellular pathophysiology.