Background The MIND diet supports healthy cognitive aging. Yet, a challenge remains to identify individuals who do not adhere to the MIND and could be at risk for accelerated cognitive decline. A multi-metabolite biomarker panel could facilitate population screening. Objectives To determine and validate a blood metabol...
Jeanne Neuffer, R. González-Domínguez, S. Lefèvre-Arbogast et al.· The journal of prevention of...· 0 citations
BACKGROUND Cognitive resilience to Alzheimer’s disease (AD) can be modelled in amyloid-expressing rodents through early handling (EH). This study investigated how EH and sex affect cognition and pathology over time. METHODS We assessed cognition (open field, object recognition test, Barnes maze) in 6- and 12-month-old...
M. Carrigan, Jeniffer Sanguino-Gómez, Melis Bayer-Var et al.· bioRxiv· 0 citations
Regular physical activity promotes brain health, yet the underlying mechanisms remain incompletely understood. Repetitive activation of neurons results in accumulation of the nuclear transcription factor ΔFOSB, a long-lived splice variant of FOSB. Long-term voluntary wheel running (VWR), a behavioral paradigm that mimi...
Marene H. Hardonk, Rick Wenning, J. Stofberg et al.· eNeuro· 0 citations
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