Author

P. Hoskisson

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Open access Sep 2026

A bacterial Rhesus transporter retunes a structurally conserved ammonium pore into a reversible nitrogen valve

How conserved proteins acquire new physiological functions is a central question in molecular evolution. Rather than inventing new architectures, evolution often repurposes existing scaffolds, preserving core structural features while retuning the molecular logic that connects mechanism to physiology. Membrane transpor...

Adriana Bizior, Ming-Yu Qin, Peter Henderson et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

Lipid-associated architecture and divergent ammonium transport distinguish a bacterial Rhesus protein

Nitrification is a major process in the global nitrogen cycle, initiated by the oxidation of ammonia to nitrite. The ammonia-oxidising bacterium Nitrosomonas europaea catalyses this first and rate-limiting step and depends on ammonium both as an energy substrate and as a nitrogen source, making ammonium acquisition cen...

Benjamin F. Cooper, Adriana Bizior, Reza Talandashti et al. · bioRxiv · 1 citation

Open access Aug 2026

Genome evolution during the domestication of an antibiotic-producing Streptomyces strain

Findings reveal that artificial selection shapes genome evolution in industrial strains, balancing production gains with metabolic trade-offs, and shows that many of the evolutionary processes in industrial strain improvement programmes mirror those at play during natural selection.

John T. Munnoch, D. Larcombe, Rebecca E. McHugh et al. · bioRxiv · 0 citations