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Open access Sep 2026

A Thiophilic Metal-Mediated Cysteine S -Detritylation Strategy: Enhancing Orthogonality in Solid-Phase Peptide Synthesis

The selective manipulation of cysteine residues in solid-phase peptide synthesis (SPPS), beyond disulfide bridge formation, remains challenging, and an efficient protocol for the selective removal of the widely used trityl (Trt) protecting group under solid-phase conditions has yet to be established. To overcome this...

Salvatore Mottola, R. Bellavita, I. Boccino et al. · 0 citations
Review Open access Jul 2026

Chemical Optimization of Temporin A–L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs

Temporins A–L, a family of short antimicrobial peptides isolated from the skin secretions of Rana temporaria, have emerged as promising scaffolds for the development of novel anti‐infective agents. However, their therapeutic translation is limited by issues such as modest selectivity, susceptibility to proteolytic degr...

I. Boccino, P. Grieco, F. Merlino · 0 citations

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