Author

P. Fadda

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Open access Aug 2026

Melatonin system integrity shapes gut-brain interaction in schizophrenia-derived microbiota transplant phenotype in mice.

AIMS This study investigates whether the melatonin (MLT) system modulates the behavioral, neurophysiological and neurochemical effects of fecal microbiota transplantation (FMT) from individuals with schizophrenia (SCZ), highlighting the role of the tryptophan (Trp) to MLT and kynurenine (Kyn) pathways. MATERIALS AND...

B. Barzon, A. Shkodra, M. D'Incalci et al. · Life Science · 0 citations

Open access Sep 2026

668. Serotonin, melatonin, and kynurenines: bridging neurochemical pathways in schizophrenia and beyond

Investigating the interplay between Trp metabolism, inflammation, and gut microbiota in modulating cognitive and metabolic phenotypes in schizophrenia suggests that dysregulated Trp metabolism acts as a translational bridge connecting genetic background, metabolic status, and microbiota-derived signals to SCZ pathophys...

B. Barzon, A. Shkodra, S. Nasini et al. · International Journal of Neu... · 0 citations

Open access Aug 2026

Antinociceptive properties of an oral formulation of Δ9-tetrahydrocannabinol in aqueous 2-hydroxypropyl-β-cyclodextrin in female rats

Background Cannabis derivatives have been reported to possess antinociceptive properties. However, oral delivery is limited by poor bioavailability, stability, and reliability of effects. Previously, we reported an analgesic effect of the aqueous complex Δ9-tetrahydrocannabinol/2-hydroxypropyl-β-cyclodextrin (THC/HPβCD...

F. Bagheri, M. Scherma, E. Murru et al. · bioRxiv · 0 citations