P. Deissler

Non-invasive electrocardiographic imaging of torsades de pointes in an ovine model of drug-induced QT prolongation: recovery dispersion sets the stage, and abnormal impulse formation pulls the trigger

Torsades de pointes (TdP) arise from a dynamic spatiotemporal interplay between arrhythmogenic substrate and triggering events. Most existing in-vivo models investigating TdP rely on invasive surgical cardiac access, which alters electromechanical function of the heart and autonomic influences, thus limiting thei...