Author

P. D. Macruz

3 papers indexed here

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Open access Oct 2026

Synthesis, Antiparasitic Activity, and ADME Profile of Morpholinephenylbenzamides: A Pharmacological Study Against Chagas Disease and Visceral Leishmaniasis

Chagas disease and leishmaniasis are neglected tropical diseases with limited treatment options. This study reports a hit‐to‐lead optimization of morpholinephenylbenzamides, starting from hit 1, which showed potent activity against Trypanosoma cruzi (IC50 0.29–0.76 μM) and Leishmania infantum (IC50 10.7 μM), despite a...

D. Farago, Daniela de Melo Resende, Mariza Gabriela Faleiro de Moura Lodi Cruz et al. · ChemMedChem · 0 citations

Open access Oct 2026

Influence of Extraction Technique and Solvent on the Recovery of Bioactive Compounds from Eugenia uniflora L. Fruits: Antioxidant, Antimicrobial, and UHPLC-MS/MS Characterization

Fruits of Eugenia uniflora L. are rich in phenolic compounds and flavonoids, highlighting their potential as a source of bioactive compounds for nutraceutical development; however, extraction conditions can substantially influence the chemical composition and biological activity of the resulting extracts. This study ev...

L. Pessanha, Mariana Dalmagro, Larissa Aparecida Engel et al. · Nutraceuticals · 0 citations

Open access Sep 2026

Effects of Mono‐ and Dicapsaicinoid Functionalization on the Physicochemical Properties and Antimicrobial Photodynamic Activity of Protoporphyrin IX

Antimicrobial photodynamic therapy (aPDT) is a promising alternative for combating multidrug‐resistant bacteria and overcoming limitations of conventional antimicrobial treatments. To improve aPDT performance, two Protoporphyrin IX (PpIX) derivatives functionalized with one or two capsaicin fragments were synthesized a...

I. V. da Cunha, G. G. Calefi, N. B. S. Silva et al. · ChemMedChem · 0 citations