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P. D

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Review Open access Sep 2026

ROS/HIF-1 signalling in alveolar macrophages: implications for lung fibrosis.

Alveolar macrophages (AMs) in idiopathic pulmonary fibrosis (IPF) display stabilisation of hypoxia inducible factor (HIF)-1 despite their residence within the well oxygenated alveolar space. This highlights a contradiction between oxygen supply and hypoxic signalling in the fibrotic lung. This inconsistency implies th...

J. 'e, Thickett Dr, P. D et al. · 0 citations

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