SUMMARY Transcriptomic profiling is widely applied to characterize cellular gene expression, yet existing approaches lyse cells and preclude direct analysis of transcriptional dynamics in the same sample over time. We addressed this limitation by engineering mammalian cells to “self-report” their transcriptional states...
M. Najia, Anna Le, Jacob Borrajo et al.· Cell· 0 citations
This work defines the requirements for cell-substrate adhesion in cultured human cells using orthogonal, large-scale functional genetic approaches and identifies established and uncharacterized regulators of adhesion, including genes involved in mitosis, focal adhesions, actin regulation, and membrane trafficking.
Kaitlyn Manzer, Kuan-Chung Su, Matteo Di Bernardo et al.· bioRxiv· 0 citations
It is shown that myeloid-derived suppressor cells (MDSCs) act as a key immunologic pivot point in severe COVID-19, and this multimodal and high-dimensional dataset with curated clinical metadata provides a foundational and clinically relevant resource for modeling host immune response biology in health and disease.
Kamil Slowikowski, Pritha Sen, C. Cosgriff et al.· Journal of Immunology· 0 citations
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