Author

P. M. Biobank

2 papers indexed here

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Review Open access Sep 2026

Causal relationship between liver fat reduction and clinical outcomes in human genetic studies and randomized clinical trials of metabolic-dysfunction associated steatohepatitis

Reliance on invasive liver biopsy endpoints is a major limiting factor in new therapeutic development for metabolic dysfunction-associated steatohepatitis (MASH). While liver fat accumulation is considered a driver of early disease, liver fat reduction is not recognized as a surrogate endpoint by health authorities. He...

N. Verweij, G. Hindy, Q. Nguyen et al. · medRxiv · 0 citations

Open access Aug 2026

Pathway Modeling of Genomic and Tissue-Specific Transcriptomic Architecture Identifies Personalized Mechanisms of Atrial Fibrillation Risk

A pathway-level multi-omics representation learning framework that converts individual genetic profiles into interpretable biological features by integrating GWAS-derived pathway burden scores with tissue-specific transcriptomic pathway signals is developed, providing a framework for interpretable genomic stratificatio...

R. Venkatesh, R. Deo, T. Cappola et al. · medRxiv · 0 citations