Author

P. Bieniasz

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Open access Aug 2026

Genetic innovation in coronaviruses driven by a viral nuclease

It is shown that non-structural protein-15 (NSP15), a nuclease encoded by coronaviruses, can drive the acquisition of a class of insertion mutations, and numerous examples of potential furin cleavage site acquisition and replacement through insertion mutation during the normal course of coronavirus replication are found.

C. Bianco, Alex C. Stabell, Manivel Lodha et al. · bioRxiv · 0 citations

Open access Aug 2026

Structural and mutational analyses define distinct molecular routes to broad SARS-CoV-2 receptor-binding domain recognition

Two human-derived monoclonal antibodies are characterized that recognize conserved epitopes on the SARS-CoV-2 RBD and retain activity across antigenically distinct variants, and conserved, mutationally constrained epitopes may serve as targets for vaccines designed to elicit antibody responses resilient to ongoing SARS-CoV-2 evolution and future sarbecovirus emergence.

M. Abernathy, William B. Foreman, Jasmyn A. Lopez et al. · bioRxiv · 0 citations