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Author

Parastoo Azadi

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6 papers indexed here

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Open access Oct 2026

Identification of glycosyltransferases that synthesize pectin heteroglycan block polymers and a structural motif required for their activity

Pectin is a family of plant cell wall complex polysaccharides and proteoglycans comprised of the glycan domains homogalacturonan (HG), rhamnogalacturonan I (RG-I), and the substituted HGs rhamnogalacturonan II (RG-II), xylogalacturonan and apiogalacturonan. The number, type, and arrangement of the pectic domains in dif...

Clifford T. Okoye, Robert A. Amos, Chin-Ling Huang et al. · 0 citations
Open access Sep 2026

Autoantibodies from recovered Guillain-Barré syndrome patients exhibit altered effector functions that prevent subsequent neuron degeneration

Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy that is the leading cause of nonpoliovirus-associated acute flaccid paralysis worldwide. In most cases, GBS occurs following an infection, most commonly Campylobacter jejuni, through the induction of antibodies recognizing bacterial ganglioside-mimicking lip...

Ashley M. Rogers, Jessica L. McAlpine, Xu Yang et al. · 0 citations
Open access Sep 2026

Characterization of the Polysaccharide and Protein Composition of Neurospora crassa Conidium, Perithecium, and Ascospore Cell Walls

We carried out carbohydrate composition and carbohydrate linkage analyses on Neurospora crassa cell walls from vegetative hyphae, conidia (asexual spores), perithecia (female mating structures), and ascospores (sexual spores). We show that the composition and structure of the cell wall undergo dramatic changes during t...

Protyusha Dey, Ian M. Black, C. Heiss et al. · 0 citations
Open access Sep 2026

Genome-wide characterization of host factors involved in single-stranded RNA and DNA phage infection pathways

Single stranded RNA (ssRNA) and single stranded DNA (ssDNA) bacteriophages represent a key component of the global virome, yet the host genetic networks supporting their infection cycles remain poorly understood. Here, we present a comprehensive, genome-wide mapping of the genetic landscape regulating infection cycles...

Isabella Murray, Roniya Thapa Magar, Denish Piya et al. · 0 citations
Open access Sep 2026

TGF-β-induced epithelial to mesenchymal transition drives proteoglycan binding specificity of HPV-based drug conjugates for cancer cells

Background Human papillomaviruses (HPVs) utilize specifically modified proteoglycans (PGs) within the basement membrane as attachment factors prior to cell entry and infection. Similarly modified PGs are also found on cancer cells, which enables HPV with tumor-selective binding properties and highlights the potential d...

N. Fons, R. Kines, P. Azadi et al. · 0 citations
Open access Aug 2026

Pectin O-3 deacetylation by Arabidopsis thaliana pectin acetylesterase 11 is important for sequential homogalacturonan degradation.

Pectin is a complex plant cell wall polysaccharide whose galacturonic acid residues can be acetylated at O-2 and/or O-3 positions. The degree of acetylation is regulated by pectin acetyl esterase (PAE, EC 3.1.1.6). However, the structure and function of plant PAEs is unclear, impairing our understanding of the role of...

Juliette Chislard, Liang Zhang, Romain Roulard et al. · 0 citations

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