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Author

Ozlem Keskin

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Open access Oct 2026

PDI-Spot: A Robust Representation Learning Framework for Identifying Energetic Hotspots in Protein–DNA Complexes

The binding affinity of protein–DNA complexes is concentrated within a subset of interface residues, called “hotspots”, which are critical for maintaining stable interactions. Therefore, identifying these energetic anchors is essential for elaborating on how mutations disrupt transcriptional regulation and for identi...

Esra Basaran, A. Gursoy, Ozlem Keskin et al. · 0 citations
Review Open access Sep 2026

Molecular Glue Degraders in Early Development for Cancer Therapy.

Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein-protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E...

E. Ozdemir, H. Jang, Ozlem Keskin et al. · 0 citations

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