Özge Kandemir

Multifactorial mechanisms of 5-fluorouracil-induced cardiotoxicity and the cardioprotective role of gallic acid

18β-glycyrrhetinic acid ameliorates ifosfamide-induced nephrotoxicity by suppressing Wnt3a/IL-17A-driven inflammatory signaling, ER stress, and apoptosis while preserving ZO-1 integrity

Protective Effects of Folic Acid Against Indomethacin-Induced Liver Injury: Involvement of Nrf2/HO-1, NF-κB, and Apoptotic Signaling Pathways

The aim of protective role of folic acid (FA) against indomethacin (IND)-induced hepatotoxicity in rats. In particular, the study focused on the capacity of FA to mitigate oxidative stress-related hepatic injury. The results demonstrated that FA treatment markedly attenuated liver damage when compared with the untreate...

Neuroprotective potential of chrysin against ketamine-induced neurotoxicity: Effects on behavioral changes, oxidative stress, and neuroinflammation.

AIM Ketamine (KTM) is widely used in clinical settings for its anesthetic, analgesic, and antidepressant properties. However, prolonged or repeated KTM exposure can induce neurotoxicity through oxidative stress, neuroinflammation, and apoptotic mechanisms. This study investigated the neuroprotective effects of Chrysin...

Betaine Alleviates Favipiravir-induced Ovarian and Uterine Toxicity by Regulating Oxidative, Inflammatory, Cellular Death, Steroidogenic, Hormonal, and Histopathological Changes

FVP caused multifaceted oxidative, inflammatory, apoptotic, and hormonal damage in ovarian and uterine tissues, while BTN significantly reduced these effects, preserving tissue integrity and function.