Author

Ondine Cleaver

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Open access Aug 2026

Functional divergence of WWC family proteins in human endothelial cells

The Hippo signaling pathway is increasingly recognized as a key regulator of endothelial cell (EC) proliferation, migration and vascular development. However, the roles of its upstream scaffold proteins remain poorly understood. Although WWC family proteins are widely regarded as functionally redundant activators of LA...

Tuli Pramanik, Austin Mills, Ondine Cleaver · bioRxiv · 0 citations

Open access Sep 2026

Conserved C-terminal residues adjacent to the canonical PDX1 homeodomain are required for chromatin occupancy and pancreas development.

Essential roles for the PDX1 transcription factor in pancreatic development and β-cell function are well-known, yet the structure-function relationships of domains within its C-terminus remain incompletely defined. We identified a focal intrinsically disordered region (IDR) spanning residues 207-223 of the Pdx1 C-termi...

Anthony S. Wokasch, Muhammad Shamoon, Courtney Campbell et al. · Development · 0 citations