Author

Olivia Tang

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Open access Jul 2026

Expanding the scope of protein language modeling to protein-protein interactions with MSA Pairformer.

Multiple sequence alignment (MSA) Pairformer is presented, a protein language model that builds on AlphaFold2/3's bidirectional refinement between sequence and pairwise residue representations to accurately model the evolution of protein-protein interactions, despite training exclusively on individual chains.

Yo Akiyama, Zhidian Zhang, Olivia Tang et al. · Cell · 3 citations