Oliver Daumke

Fragment-Based Covalent Targeting of Lysines at the Allosteric Latch Site of SHP2

Covalent mechanism of action is a powerful way to modulate challenging drug targets. Here, we present a streamlined workflow that combines covalent fragment screening (electrophile first approach) and ligand-first strategy to identify covalent inhibitors targeting lysine residues in the allosteric latch site of SHP2...