Olisaemeka D. Ogbue

Emergency hematopoiesis in sepsis: A pathway to myeloid clonal expansion

Clonal hematopoiesis of indeterminate potential (CHIP) arises from somatic mutations in hematopoietic stem cells (HSCs) that confer a fitness advantage and is associated with increased risks of myeloid neoplasia, cardiovascular disease, and mortality. 1 – 5 Although aging is a major determinant of CHIP, the contributio...