Author

Obeid Shanab

South valley University

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Open access Jul 2026

Citrus flavonoids mitigate the cisplatin-induced ovarian toxicity via dual modulation of Nrf2/HO-1 pathway and NF-κB axis

It is demonstrated that NG and HP could protect ovarian granulosa cells from CIS-induced damage through dual regulation of the Nrf2/heme oxygenase-1 (HO-1) antioxidant and nuclear factor kappa B (NF-κB) inflammatory axis, highlighting their potential as adjuvant therapies to mitigate chemotherapy-induced ovarian toxicity.

Ahmed Abdeen, Obeid Shanab, Mohammed H. Hassan et al. · Frontiers in Pharmacology · 0 citations

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