Matching drug and polymer for efficient delivery of anti-inflammatory drugs: PLGA, polyesteramides, and acetalated dextran
L. Klepsch, P. Dahlke, Mira Behnke et al.
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Findings reveal compound 11 as a promising anti-inflammatory agent supporting dual 5-LOX/sEH inhibition, coupled with Nrf2 activation, as a viable strategy for AP, showing potent in vitro inhibition of both enzymes and satisfactory metabolic stability.
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