O. Stepanenko

Spontaneous aging of mature amyloids alters structural stability, cytotoxicity, and susceptibility to biological clearance.

Accumulation of amyloid fibrils is a key factor in the pathogenesis of progressive diseases, including neurodegenerative disorders such as Alzheimer's and Parkinson's disease, as well as systemic amyloidosis. Although amyloid deposits are known to persist in vivo for years or even decades, it remains unclear how the st...