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Author

O. Sadeghi-Alavijeh

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Open access Aug 2026

Genetic and environmental risk factors for intracranial aneurysm and subarachnoid haemorrhage among patients with Autosomal Dominant Polycystic Kidney Disease

Intracranial aneurysms (IA) and their rupture (subarachnoid haemorrhage, SAH) are a rare but serious complication of autosomal dominant polycystic kidney disease (ADPKD). Both genetic and environmental risk factors contribute to the pathogenesis of IA and SAH, but specific information on risk factors in the ADPKD popul...

L. Urpa, S. Osman, T. Visser et al. · 0 citations
Open access Sep 2026

Whole-genome sequencing characterizes monogenic and polygenic contributions to structural kidney and urinary tract malformations.

The diagnostic yield for monogenic kidney disease was only 4.9% in this cohort, with common and low frequency variants potentially accounting for some of the missing heritability of CAKUT, although the confidence intervals were wide.

M. Chan, O. Sadeghi-Alavijeh, Seth du Preez et al. · 0 citations

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