Author

O. Rascol

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Review Open access Sep 2026

Clinical trials in late-stage Parkinson's disease

Late-stage Parkinson's disease (LSPD) represents an under-recognized and under-studied phase of PD characterized by severe axial motor symptoms, high non-motor burden, cognitive impairment, functional dependence, and substantial caregiver involvement. Despite its major clinical and socioeconomic impact, LSPD seem to be...

Margherita Fabbri, Silvia Gallo, Tiago Machado et al. · Journal of Parkinson's Disea... · 0 citations

Open access Sep 2026

Radiological signature of levodopa responsiveness in Parkinson's disease: A data driven approach in a deep brain stimulation cohort.

BACKGROUND Levodopa is the gold-standard therapy for motor symptoms in Parkinson's disease (PD). However, individual responses vary substantially among patients, and the biological mechanisms underlying this heterogeneity remain incompletely understood. OBJECTIVE This study aimed to investigate the neural substrates...

N. Betrouni, Maia Ketelers, Romain Viard et al. · Neurobiology of Disease · 0 citations

Oct 2026

Levodopa Use and Characteristics of Freezing-of-Gait in Patients With Parkinson Disease in the NS-Park and PPMI Cohorts.

BACKGROUND AND OBJECTIVES Recent reports have suggested that levodopa exposure may contribute to freezing of gait (FOG), but this relationship remains controversial because of confounding by disease severity and duration. Our goal was to assess the relationship between levodopa use and FOG incidence and severity. MET...

Raquel Barbosa, P. Bastos, O. Rascol et al. · Neurology · 0 citations