Depressive symptoms in adolescence may represent intermediary phenotypes or transdiagnostic susceptibilities related to high polygenic risk for schizophrenia (PRSscz), which appears to explain age-specific fluctuations in depressive symptoms.
Veikka Lavonius, L. Lyytikäinen, Elina Sormunen et al.· Schizophrenia Research· 0 citations
BACKGROUND
Lipoprotein(a) [Lp(a)] can be reported as mass (mg/dL) or particle concentration (nmol/L). Because Lp(a) acts at the particle level, molar concentration may better reflect biologically relevant exposure.
OBJECTIVE
To compare molar- and mass-based Lp(a) in relation to cardiovascular outcomes, risk classific...
O. Raitakari, M. Knuuti, A. Linko-Parvinen et al.· Journal of Clinical Lipidolo...· 0 citations
Summary Paragraph Personality traits describe stable differences in how people think, feel, and behave and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustness, generalizability,...
T. Schwaba, Margaret L. Clapp Sullivan, W. Akingbuwa et al.· Nature· 5 citations· ⚡1
BACKGROUND
Fatty liver is the most common chronic liver disease globally and is associated with increased cardiovascular risk. Evidence specifically addressing fatty liver and cardiovascular outcomes in young adults from European population-based cohorts remains scarce.
METHODS
Fatty liver was assessed by abdominal u...
O. Raitakari, K. Pahkala, S. Rovio et al.· Atherosclerosis· 0 citations
Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood factors and polygenic risk scores (PRSs). Data fro...
Rooholla Poursoleymani, Ioannis Papathanail, Lorenzo Brigato et al.· Scientific Reports· 0 citations
Inverse associations between Lp(a) and fasting glucose were observed in males and higher adult Lp(a) concentrations were prospectively associated with lower risk of incident type 2 diabetes, in the prospective Young Finns Study cohort.
M. Knuuti, N. Kartiosuo, K. Pahkala et al.· Cardiovascular Diabetology· 0 citations
Higher level of adolescent BMI partly mediated the association between higher BMI-PRS and accelerated biological aging from late adolescence to middle adulthood, indicating that high BMI in adolescence may accelerate biological aging.
Anni Pitkänen, Anna Kankaanpää, E. Raitoharju et al.· International Journal of Obe...· 0 citations
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